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CS-W001157 4
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4-Methoxy-2-methylpyrimidin-5-amine

  • CAS No. 53135-45-8

  • Cat. No. CS-W022202
  • Molecule weight139.16
  • Purity≥97%
  • MDL No.MFCD09743865

*For research and further manufacturing use only, not for direct human use.

4-Methoxy-2-methylpyrimidin-5-amine|CS-W022202

Structure of 53135-45-8

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General Information

  • CAS No. 53135-45-8
  • Cat. No. CS-W022202
  • Purity ≥97%
  • MDL No. MFCD09743865
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₉N₃O
  • Molecular Weight 139.16
  • Synonym(s) 4-Methoxy-2-methyl-5-pyrimidinamin
  • SMILES NC1=CN=C(C)N=C1OC

Description

4-Methoxy-2-methylpyrimidin-5-amine features a pyrimidine core bearing a methoxy group at C4 and a methyl substituent at C2, enhancing solubility and metabolic stability. The aniline-like amine at C5 enables facile coupling reactions in medicinal chemistry. This scaffold integrates readily into kinase inhibitors and antiviral agents due to its favorable electronic profile and planar geometry.

Application

4-Methoxy-2-methylpyrimidin-5-amine serves as a versatile building block in medicinal chemistry, enabling efficient access to pyrimidine-based scaffolds. Its ortho-substituted structure supports regioselective functionalization and exhibits favorable bench stability, facilitating straightforward purification and integration into standard coupling reactions. The molecule functions as a key intermediate in the synthesis of kinase inhibitors and other bioactive heterocycles, leveraging its dual electron-donating groups for enhanced reactivity in cross-coupling and cyclization protocols.

Synthesis

  • Route1

    References

    • Helvetica Chimica Acta, , vol. 41, p. 1806,1812
  • Route2

    References

    • Helvetica Chimica Acta, , vol. 41, p. 1806,1812
  • Route3

    References

    • Helvetica Chimica Acta, , vol. 41, p. 1806,1812

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   61.03
  • LogP   0.37582
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

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