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CS-W001157 4
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2'-Deoxy-2'-fluoroarabinoadenosine

  • CAS No. 20227-41-2

  • Cat. No. CS-0513841
  • Purity≥98%
  • MDL No.MFCD12911815

*For research and further manufacturing use only, not for direct human use.

2'-Deoxy-2'-fluoroarabinoadenosine|CS-0513841

Structure of 20227-41-2

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General Information

  • CAS No. 20227-41-2
  • Cat. No. CS-0513841
  • Purity ≥98%
  • MDL No. MFCD12911815
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₂FN₅O₃
  • Molecular Weight 269.23
  • Synonym(s) None
  • SMILES O[C@H]1[C@H](F)[C@H](N(C=N2)C3=C2C(N)=NC=N3)O[C@@H]1CO

Description

2'-Deoxy-2'-fluoroarabinoadenosine is a fluorinated nucleoside analog featuring a 2'-fluoro substitution in the arabinose sugar configuration. This modification enhances metabolic stability and resistance to enzymatic degradation, enabling prolonged intracellular retention. The compound integrates efficiently into RNA during synthesis, acting as a potent chain terminator with applications in antiviral research and targeted nucleic acid labeling.

Application

2'-Deoxy-2'-fluoroarabinoadenosine serves as a valuable nucleoside analog in antiviral and anticancer research, featuring a 2'-fluoro substitution that enhances metabolic stability and resistance to enzymatic degradation. The arabinose configuration imparts distinct conformational rigidity, enabling selective incorporation into oligonucleotides and facilitating studies in RNA-directed therapeutics. Its bench-stable solid form and compatibility with standard coupling protocols make it a practical building block for synthetic oligonucleotide workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   119.31
  • LogP   -1.0028
  • H_Acceptors   8
  • H_Donors   3
  • Rotatable_Bonds   2

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