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CS-W001157 4
Total: USD 88.00

6-Bromo-2,3-difluorobenzaldehyde

  • CAS No. 360576-04-1

  • Cat. No. CS-W014748
  • Purity≥96%
  • MDL No.MFCD07368119

*For research and further manufacturing use only, not for direct human use.

6-Bromo-2,3-difluorobenzaldehyde|CS-W014748

Structure of 360576-04-1

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General Information

  • CAS No. 360576-04-1
  • Cat. No. CS-W014748
  • Purity ≥96%
  • MDL No. MFCD07368119
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₃BrF₂O
  • Molecular Weight 221.00
  • Synonym(s) None
  • SMILES O=CC1=C(Br)C=CC(F)=C1F

Description

6-Bromo-2,3-difluorobenzaldehyde features a strategically positioned bromine and two fluorine atoms that enhance electronic withdrawal and metabolic stability. This electron-deficient aromatic aldehyde integrates readily into cross-coupling reactions and serves as a key building block for pharmaceutical intermediates and functional materials.

Application

6-Bromo-2,3-difluorobenzaldehyde serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling direct incorporation of bromo- and difluoro-substituted aryl motifs. Its aldehyde functionality facilitates efficient Suzuki-Miyaura coupling, reductive amination, and Ullmann-type cross-couplings. The molecule exhibits excellent bench stability and compatibility with diverse functional groups, simplifying purification and scale-up.

Synthesis

  • Route1
    • null|null
      348-61-8
    • null|null
      68-12-2
    • ~80%
    • In-stock
      6-Bromo-2,3-difluorobenzaldehyde|CS-W014748
      360576-04-1

    References

    • ELI LILLY AND COMPANY Patent: WO2004/9578 A2, 2004 ; Location in patent: Page 40 ; WO 2004/009578 A2
  • Route2

    References

    • MERCK PATENT GMBH Patent: WO2005/105772 A1, 2005 ; Location in patent: Page/Page column 56 ;
  • Route3
    • null|null
      768-66-1
    • null|null
      348-61-8
    • ~57%
    • In-stock
      6-Bromo-2,3-difluorobenzaldehyde|CS-W014748
      360576-04-1

    References

    • Clariant GmbH Patent: US2001/50352 A1, 2001 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   2.5398
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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