5-Bromo-2,3-difluorobenzaldehyde

Name: 5-Bromo-2,3-difluorobenzaldehyde
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 633327-22-7
Cat. No. CS-W001611
Purity≥98%
MDL No.MFCD08669446

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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5-Bromo-2,3-difluorobenzaldehyde|CS-W001611

Structure of 633327-22-7

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General Information

CAS No. 633327-22-7
Cat. No. CS-W001611
Purity ≥98%
MDL No. MFCD08669446
Storage 4°C, protect from light, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₃BrF₂O
Molecular Weight 221.00
Synonym(s) 5-BROMO-2,3-DIFLUORO-BENZALDEHYDE
SMILES O=Cc1cc(Br)cc(c1F)F

Description

5-Bromo-2,3-difluorobenzaldehyde features a trifunctional aromatic core with bromine and two fluorine substituents positioned ortho to the aldehyde group. This electron-deficient scaffold enables efficient coupling reactions in cross-coupling and transition-metal catalyzed transformations. The aldehyde functionality offers direct access to imines, hydrazones, and other derivatives. Bench-stable under standard conditions, it serves as a key building block for pharmaceutical intermediates and functional materials.

Application

5-Bromo-2,3-difluorobenzaldehyde serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient access to fluorinated aromatic scaffolds. Its orthogonal reactivity profile—combining bromine for Pd-catalyzed cross-coupling and difluoro substitution for enhanced metabolic stability—facilitates rapid diversification. The aldehyde functionality supports direct derivatization via imine formation or reduction, while the compound exhibits excellent bench stability and straightforward purification.

Synthesis

Route1
- In-stock
  
  2646-91-5
- ~46%
- In-stock
  
  633327-22-7
References
- NOVIRA THERAPEUTICS, INC.; HARTMAN, George D.; FLORES, Osvaldo A. Patent: WO2013/96744 A1, 2013 ; Location in patent: Page/Page column 229 ;
Route2
- 633327-21-6
- ~%
- In-stock
  
  633327-22-7
References
- Eisai Co., Ltd. Patent: EP1510516 A1, 2005 ; Location in patent: Page/Page column 92 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 17.07
LogP 2.5398
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Aldehyde

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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5-Bromo-2,3-difluorobenzaldehyde

CAS No. 633327-22-7

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