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CS-W001157 4
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Cyclopropyl(piperazin-1-yl)methanone

  • CAS No. 59878-57-8

  • Cat. No. CS-D0807
  • Purity≥98%
  • MDL No.MFCD06369645

*For research and further manufacturing use only, not for direct human use.

Cyclopropyl(piperazin-1-yl)methanone|CS-D0807

Structure of 59878-57-8

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General Information

  • CAS No. 59878-57-8
  • Cat. No. CS-D0807
  • Purity ≥98%
  • MDL No. MFCD06369645
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₄N₂O
  • Molecular Weight 154.21
  • Synonym(s) None
  • SMILES O=C(N1CCNCC1)C2CC2

Description

Cyclopropyl(piperazin-1-yl)methanone features a rigid cyclopropyl group paired with a piperazinyl moiety, delivering enhanced metabolic stability and improved solubility. This structural combination enables efficient incorporation into bioactive molecules, particularly in kinase inhibitors and CNS-targeted compounds, where balanced lipophilicity and polarity are critical for permeability and target engagement.

Application

Cyclopropyl(piperazin-1-yl)methanone serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard amide coupling and reductive amination protocols. Its cyclopropyl-piperazine motif offers favorable metabolic stability and enhanced solubility, facilitating integration into drug-like scaffolds. The compound exhibits bench stability, ease of purification, and broad functional group tolerance, making it well-suited for iterative synthesis campaigns in API development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07,GHS09
Signal Word : Danger
UN#: 3077
Class : 9
Packing Group : Ⅲ
Hazard Statements : H302-H317-H318-H410
Precautionary Statements : P261-P264-P270-P272-P273-P280-P302+P352-P391-P501

Quality Control

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Computational Chemistry Data

  • TPSA   32.34
  • LogP   -0.1718
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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