Clofarabine

Name: Clofarabine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 123318-82-1
Cat. No. CS-0373
Purity≥98%
MDL No.MFCD00871077

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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Structure of 123318-82-1

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Description

Daminozide is a commonly used plant growth regulator, which acts by inhibiting 2-oxoglutarate-dependent dioxygenase activity in the gibberellin biosynthesis pathway.Daminozide may be used as a reference standard for the determination of daminozide in fruits and vegetables by liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS).It may also be used as a reference standard for the determination of daminozide in Ophiopogon japonicus plants and soil by ultra-performance liquid chromatography-triple quadrupole tandem mass spectrometry (UPLC-QqQ-MS/MS).

Application

Clofarabine serves as a fluorinated purine nucleoside analog that functions as a potent prodrug inhibitor of DNA synthesis. Its trifluoromethyl group enhances metabolic stability and cellular uptake, enabling efficient incorporation into DNA during replication. This leads to chain termination and inhibition of ribonucleotide reductase, disrupting deoxynucleotide pools. Clofarabine is particularly valuable in the synthesis of antitumor nucleoside derivatives and serves as a key building block in the development of targeted therapies for hematologic malignancies.

General Information

CAS No. 123318-82-1
Cat. No. CS-0373
Purity ≥98%
MDL No. MFCD00871077
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₁ClFN₅O₃
Molecular Weight None
Synonym(s) None
SMILES O[C@H]1[C@H](F)[C@H](N(C=N2)C3=C2C(N)=NC(Cl)=N3)O[C@@H]1CO

Computational Chemistry Data

TPSA 119.31
LogP -0.3494
H_Acceptors 8
H_Donors 3
Rotatable_Bonds 2

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS06
Signal Word : Danger	UN#: 2811
Class : 6.1	Packing Group : Ⅲ
Hazard Statements : H300
Precautionary Statements : P264-P270-P330-P405-P501

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Other Classifications

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Life Science Nucleosides & Nucleotides

Biochemistry Biochemicals and Reagents Nucleosides, Nucleotides, Oligonucleotides Nucleoside Analogs

Biochemistry Biochemicals and Reagents Nucleosides, Nucleotides, Oligonucleotides Nucleosides

Biochemistry Biochemicals and Reagents Pharmaceutical Research Reagents Antitumor Research Reagents

Biochemistry Pharmaceutical Development and Drug Discovery Research Pharmaceutical Research Reagents Antitumor Research Reagents

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Clofarabine

CAS No. 123318-82-1

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