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CS-W001157 4
Total: USD 88.00

Propargyl-PEG1-NH2

  • CAS No. 122116-12-5

  • Cat. No. CS-0063716
  • Purity≥96%
  • MDL No.MFCD16713446

*For research and further manufacturing use only, not for direct human use.

Propargyl-PEG1-NH2|CS-0063716

Structure of 122116-12-5

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General Information

  • CAS No. 122116-12-5
  • Cat. No. CS-0063716
  • Purity ≥96%
  • MDL No. MFCD16713446
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₉NO
  • Molecular Weight 99.13
  • Synonym(s) None
  • SMILES C#CCOCCN

Description

Propargyl-PEG1-NH2 features a reactive alkyne handle flanked by a short, hydrophilic PEG spacer and a primary amine group. This bifunctional architecture enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) while maintaining solubility in aqueous environments. Ideal for bioconjugation workflows requiring site-specific labeling and minimal steric interference.

Application

Propargyl-PEG1-NH₂ serves as a versatile bifunctional building block for click chemistry and bioconjugation, combining a terminal alkyne for CuAAC reactions with a primary amine for amide coupling. Its short PEG spacer enhances solubility and reduces steric hindrance, enabling efficient conjugation in peptide, protein, and oligonucleotide modifications. The compound exhibits excellent bench stability and is readily purified by standard chromatographic methods, making it ideal for routine synthesis and high-throughput applications.

Safety Information

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GHS Pictogram :
GHS No : GHS02,GHS05
Signal Word : Danger
UN#: 2734
Class : 8 (3)
Packing Group : Ⅱ
Hazard Statements : H226-H314
Precautionary Statements : P210-P233-P240-P241-P242-P243-P260-P264-P280-P301+P330+P331-P304+P340-P363-P370+P378-P405-P501

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Computational Chemistry Data

  • TPSA   35.25
  • LogP   -0.4051
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   3

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