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CS-W001157 4
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6-Amino-1-hexyne

  • CAS No. 15252-45-6

  • Cat. No. CS-0106594
  • Purity≥95%
  • MDL No.MFCD09923614

*For research and further manufacturing use only, not for direct human use.

6-Amino-1-hexyne|CS-0106594

Structure of 15252-45-6

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General Information

  • CAS No. 15252-45-6
  • Cat. No. CS-0106594
  • Purity ≥95%
  • MDL No. MFCD09923614
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₁N
  • Molecular Weight 97.16
  • Synonym(s) None
  • SMILES C#CCCCCN

Description

6-Amino-1-hexyne features a terminal alkyne group conjugated to a primary amine, enabling efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) for bioconjugation. This bifunctional scaffold integrates seamlessly into peptide and polymer architectures, offering high reactivity under mild conditions with minimal side reactions.

Application

6-Amino-1-hexyne serves as a versatile building block for the synthesis of functionalized alkynes and nitrogen-containing heterocycles. Its terminal alkyne functionality enables reliable copper-catalyzed azide-alkyne cycloaddition (CuAAC), while the primary amine group allows for orthogonal derivatization via acylation or coupling reactions. The compound exhibits good bench stability and facilitates straightforward purification, making it suitable for modular library construction in medicinal chemistry and materials science applications.

Safety Information

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GHS Pictogram :
GHS No : GHS02,GHS05,GHS07
Signal Word : Danger
UN#: 2924
Class : 3,8
Packing Group : Ⅲ
Hazard Statements : H226-H314-H335
Precautionary Statements : P210-P233-P240-P241-P242-P243-P260-P264-P271-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P312-P363-P370+P378-P403+P233-P403+P235-P405-P501

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   0.7486
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   3

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