2-Chloro-5-cyanopyrazine

Name: 2-Chloro-5-cyanopyrazine
Brand: ChemScene
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CAS No. 36070-75-4
Cat. No. CS-W003619
Purity≥98%
MDL No.MFCD09607700

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 36070-75-4
Cat. No. CS-W003619
Purity ≥98%
MDL No. MFCD09607700
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₂ClN₃
Molecular Weight 139.54
Synonym(s) 5-Chloropyrazine-2-carbonitrile
SMILES Clc1cnc(cn1)C#N

Description

2-Chloro-5-cyanopyrazine is a heterocyclic building block featuring a chloro group at the 2-position and a cyano group at the 5-position on the pyrazine ring. This electron-deficient scaffold enables efficient coupling reactions in medicinal chemistry and materials science, offering high reactivity under standard conditions. The molecule exhibits excellent stability and compatibility with diverse synthetic transformations.

Application

2-Chloro-5-cyanopyrazine serves as a versatile building block in heterocyclic synthesis, enabling palladium-catalyzed cross-coupling reactions due to its reactive chloro group. The nitrile functionality provides additional handles for downstream transformations, including hydrolysis to carboxylic acids or reduction to aldehydes. Its stability under standard bench conditions and compatibility with diverse functional groups make it a practical choice for constructing complex pharmaceutical intermediates and agrochemical scaffolds.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 49.57
LogP 1.00168
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Cyanide/Nitrile

Building Blocks Skeleton Aromatic heterocycle compounds Pyrazine compounds

Key Words

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2-Chloro-5-cyanopyrazine

CAS No. 36070-75-4

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