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2-(Trifluoromethyl)morpholine hydrochloride

  • CAS No. 1196152-51-8

  • Cat. No. CS-0064849
  • Purity≥97%
  • MDL No.MFCD13189488

*For research and further manufacturing use only, not for direct human use.

2-(Trifluoromethyl)morpholine hydrochloride|CS-0064849

Structure of 1196152-51-8

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General Information

  • CAS No. 1196152-51-8
  • Cat. No. CS-0064849
  • Purity ≥97%
  • MDL No. MFCD13189488
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₉ClF₃NO
  • Molecular Weight 191.58
  • Synonym(s) 2-Trifluoromethyl-morpholine hydrochloride
  • SMILES FC(F)(F)C1CNCCO1.Cl

Description

2-(Trifluoromethyl)morpholine hydrochloride delivers a potent trifluoromethylated morpholine scaffold with enhanced solubility and stability under standard conditions. This bench-stable salt form facilitates direct incorporation into synthetic workflows, enabling efficient access to fluorinated heterocycles in medicinal chemistry and materials science applications.

Application

2-(Trifluoromethyl)morpholine hydrochloride serves as a stable, bench-ready building block for medicinal chemistry and catalysis. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the morpholine core provides a versatile nitrogen handle for downstream functionalization. The hydrochloride salt improves solubility and handling, enabling efficient coupling reactions and heterocycle construction in standard synthetic workflows.

Synthesis

  • Route1
    • 4-Benzyl-2-(trifluoromethyl)morpholine|CS-1215678
      1430086-47-7
    • ~89%
    • In-stock
      2-(Trifluoromethyl)morpholine hydrochloride|CS-0064849
      1196152-51-8

    References

    • Shcherbatiuk, Andriy V.; Shyshlyk, Oleg S.; Yarmoliuk, Dmytro V.; Shishkin, Oleg V.; Shishkina, Svitlana V.; Starova, Viktoriia S.; Zaporozhets, Olga A.; Zozulya, Sergey; Moriev, Roman; Kravchuk, Olga; Manoilenko, Olga; Tolmachev, Andrey A.; Mykhailiuk, Pavel K. Tetrahedron, 2013 , vol. 69, # 19 p. 3796 - 3804

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   21.26
  • LogP   0.9589
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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