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tert-Butyl (2S,6S)-2,6-dimethylpiperazine-1-carboxylate

  • CAS No. 574007-66-2

  • Cat. No. CS-0048592
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

tert-Butyl (2S,6S)-2,6-dimethylpiperazine-1-carboxylate|CS-0048592

Structure of 574007-66-2

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General Information

  • CAS No. 574007-66-2
  • Cat. No. CS-0048592
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₂₂N₂O₂
  • Molecular Weight 214.30
  • Synonym(s) (2S,6S)-tert-Butyl 2,6-dimethylpiperazine-1-carboxylate
  • SMILES C[C@H]1CNC[C@H](C)N1C(=O)OC(C)(C)C

Description

tert-Butyl (2S,6S)-2,6-dimethylpiperazine-1-carboxylate is a stereochemically defined piperazine derivative featuring two methyl groups at the 2 and 6 positions with (2S,6S) configuration. This bench-stable, moisture-tolerant building block integrates readily into complex molecular architectures, offering controlled spatial orientation for medicinal chemistry applications.

Application

tert-Butyl (2S,6S)-2,6-dimethylpiperazine-1-carboxylate serves as a stereochemically defined piperazine scaffold for medicinal chemistry applications. The tert-butyl carbamate group provides bench stability and facilitates straightforward deprotection under mild acidic conditions. The (2S,6S)-configured dimethyl substitution enables precise control over conformational flexibility and spatial orientation, enhancing binding selectivity in target-directed synthesis. This building block exhibits excellent functional group tolerance and compatibility with standard coupling protocols, enabling efficient incorporation into diverse molecular architectures.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   41.57
  • LogP   1.6037
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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