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2-(Difluoromethyl)morpholine hydrochloride

  • CAS No. 2095408-94-7

  • Cat. No. CS-0133643
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-(Difluoromethyl)morpholine hydrochloride|CS-0133643

Structure of 2095408-94-7

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General Information

  • CAS No. 2095408-94-7
  • Cat. No. CS-0133643
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature, keep dry and cool
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₀ClF₂NO
  • Molecular Weight 173.59
  • Synonym(s) Morpholine, 2-(difluoromethyl)-, hydrochloride
  • SMILES FC(C1CNCCO1)F.[H]Cl

Description

2-(Difluoromethyl)morpholine hydrochloride delivers a unique difluoromethyl group integrated into a morpholine scaffold, offering enhanced metabolic stability and improved lipophilicity. This bench-stable salt form facilitates handling in synthetic workflows, enabling efficient incorporation into bioactive molecules for medicinal chemistry applications.

Application

2-(Difluoromethyl)morpholine hydrochloride serves as a stable, bench-ready building block for fluorinated heterocyclic scaffolds. Its difluoromethyl group enables selective electrophilic substitution and facilitates metabolic stabilization in medicinal chemistry applications. The morpholine core provides excellent solubility and functional group tolerance, enabling efficient coupling reactions and derivatization under standard conditions. This compound functions effectively in both small-molecule synthesis and API intermediate development.

Safety Information

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GHS Pictogram : N/A
GHS No : N/A
Signal Word : N/A
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : N/A
Precautionary Statements : N/A

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Computational Chemistry Data

  • TPSA   21.26
  • LogP   0.6617
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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