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CS-W001157 4
Total: USD 88.00

Lenalidomide-5-aminomethyl hydrochloride

  • CAS No. 1158264-69-7

  • Cat. No. CS-0120203
  • Purity≥97%
  • MDL No.MFCD31794744

*For research and further manufacturing use only, not for direct human use.

Lenalidomide-5-aminomethyl hydrochloride|CS-0120203

Structure of 1158264-69-7

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General Information

  • CAS No. 1158264-69-7
  • Cat. No. CS-0120203
  • Purity ≥97%
  • MDL No. MFCD31794744
  • Storage -20°C, stored under nitrogen, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₁₆ClN₃O₃
  • Molecular Weight 309.75
  • Synonym(s) None
  • SMILES [H]Cl.O=C(C(N(CC1=C2C=CC(CN)=C1)C2=O)CC3)NC3=O

Description

Lenalidomide-5-aminomethyl (hydrochloride) features a strategically positioned aminomethyl group that enhances solubility and facilitates downstream conjugation. This derivative retains the core immunomodulatory scaffold of lenalidomide while introducing a reactive handle for bioconjugation, enabling targeted delivery in chemical biology applications.

Application

Lenalidomide-5-aminomethyl (hydrochloride) serves as a key synthetic intermediate for targeted immunomodulatory drug development. The pendant primary amine enables straightforward conjugation via amide or imine formation, while the retained lenalidomide core maintains pharmacophoric integrity. Bench-stable and readily purified by standard chromatography, it functions effectively in solution-phase peptide coupling and bioconjugation workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   92.5
  • LogP   -1.0561
  • H_Acceptors   6
  • H_Donors   2
  • Rotatable_Bonds   2

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