Fmoc-Gly-NH-CH2-acetyloxy

Name: Fmoc-Gly-NH-CH2-acetyloxy
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CAS No. 1599440-06-8
Cat. No. CS-0135424
Molecule weight368.38
Purity≥95%
MDL No.MFCD34184487

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General Information

CAS No. 1599440-06-8
Cat. No. CS-0135424
Purity ≥95%
MDL No. MFCD34184487
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₀H₂₀N₂O₅
Molecular Weight 368.38
Synonym(s) None
SMILES O=C(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)NCC(NCOC(C)=O)=O

Description

Fmoc-Gly-NH-CH2-acetyloxy delivers a reactive acetoxy handle for site-specific conjugation, enabling efficient coupling to nucleophilic groups under mild conditions. This stable, bench-ready reagent integrates seamlessly into peptide synthesis workflows, offering high functional group compatibility and minimal side reactions.

Application

Fmoc-Gly-NH-CH₂-acetyloxy serves as a stable, bench-ready building block for peptide synthesis and bioconjugation. The Fmoc group enables efficient orthogonal protection during solid-phase workflows, while the acetyloxy moiety provides a readily cleavable linker for controlled release of functionalized glycine derivatives. This compound facilitates rapid access to glycosylated or ester-functionalized peptides with high purity and predictable reactivity under standard deprotection conditions.

Safety Information

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Computational Chemistry Data

TPSA 93.73
LogP 2.1619
H_Acceptors 5
H_Donors 2
Rotatable_Bonds 6

Other Classifications

Building Blocks Functional Group Fmoc

Building Blocks Functional Group Amine

Building Blocks Functional Group Ester

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Life Science ADC Related Compound ADC Linker

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Biochemistry Biochemicals and Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Biochemistry Pharmaceutical Development and Drug Discovery Research Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Key Words

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Fmoc-Gly-NH-CH2-acetyloxy

CAS No. 1599440-06-8

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