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CS-W001157 4
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3-(6-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione

  • CAS No. 2304513-76-4

  • Cat. No. CS-0368405
  • Purity≥97%
  • MDL No.MFCD32667217

*For research and further manufacturing use only, not for direct human use.

3-(6-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione|CS-0368405

Structure of 2304513-76-4

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General Information

  • CAS No. 2304513-76-4
  • Cat. No. CS-0368405
  • Purity ≥97%
  • MDL No. MFCD32667217
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₁BrN₂O₃
  • Molecular Weight 323.15
  • Synonym(s) None
  • SMILES O=C(C(N(CC1=C2C=C(Br)C=C1)C2=O)CC3)NC3=O

Description

This piperidine-2,6-dione scaffold features a brominated isoindolinone moiety, delivering enhanced reactivity and stability for synthetic applications. The electron-deficient ring system enables efficient coupling in transition-metal-catalyzed transformations, while the sterically accessible core facilitates modular derivatization. Designed for robust performance under standard conditions, this compound serves as a key intermediate in medicinal chemistry campaigns targeting bioactive heterocycles.

Application

3-(6-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione serves as a versatile building block for the synthesis of isoindolinone-based scaffolds prevalent in medicinal chemistry. The bromo substituent enables palladium-catalyzed cross-coupling reactions, while the diketone functionality supports enolization and condensation processes. Its bench-stable solid form and compatibility with diverse reaction conditions facilitate efficient integration into multi-step syntheses of bioactive compounds.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

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Computational Chemistry Data

  • TPSA   66.48
  • LogP   0.6642
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   1

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