Lenalidomide-5-Br

Name: Lenalidomide-5-Br
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1010100-26-1
Cat. No. CS-0105752
Purity≥97%
MDL No.MFCD32263142

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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Structure of 1010100-26-1

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General Information

CAS No. 1010100-26-1
Cat. No. CS-0105752
Purity ≥97%
MDL No. MFCD32263142
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₃H₁₁BrN₂O₃
Molecular Weight 323.15
Synonym(s) None
SMILES O=C(C(N(CC1=C2C=CC(Br)=C1)C2=O)CC3)NC3=O

Description

Lenalidomide-5-Br features a bromine substitution at the 5-position of the phthalimide ring, enhancing its reactivity in cross-coupling processes. This derivative serves as a key intermediate for diversifying imide-based pharmaceuticals, offering improved functional group compatibility under standard coupling conditions.

Application

Lenalidomide-5-Br serves as a versatile brominated derivative enabling site-specific functionalization in the development of immunomodulatory drug analogs. The bromine substituent at the 5-position facilitates palladium-catalyzed cross-coupling reactions, supporting efficient diversification of the imidazoline core. Its bench-stable nature and compatibility with standard synthetic protocols make it a practical building block for medicinal chemistry campaigns targeting targeted protein degradation and immune modulation.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

TPSA 66.48
LogP 0.6642
H_Acceptors 5
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Life Science PROTAC Ligands for E3 Ligase

Building Blocks Functional Group Amine

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Proteolysis Targeting Chimera Research Reagents

Biochemistry Pharmaceutical Development and Drug Discovery Research Proteolysis Targeting Chimera Research Reagents

Key Words

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Lenalidomide-5-Br

CAS No. 1010100-26-1

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