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tert-Butyl 2-azaspiro[3.3]heptan-6-ylcarbamate

  • CAS No. 1118786-85-8

  • Cat. No. CS-0003948
  • Purity≥97%
  • MDL No.MFCD11858159

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 2-azaspiro[3.3]heptan-6-ylcarbamate|CS-0003948

Structure of 1118786-85-8

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General Information

  • CAS No. 1118786-85-8
  • Cat. No. CS-0003948
  • Purity ≥97%
  • MDL No. MFCD11858159
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₂₀N₂O₂
  • Molecular Weight 212.29
  • Synonym(s) None
  • SMILES O=C(OC(C)(C)C)NC1CC2(CNC2)C1

Description

tert-Butyl 2-azaspiro[3.3]heptan-6-ylcarbamate delivers a rigid, nitrogen-rich spirocyclic scaffold with enhanced metabolic stability. This bench-stable carbamate incorporates a tertiary amine within a constrained bicyclic framework, enabling precise spatial control in medicinal chemistry applications. The protecting group facilitates straightforward deprotection under mild acidic conditions, supporting rapid access to the free amine for downstream conjugation or structural diversification.

Application

tert-Butyl 2-azaspiro[3.3]heptan-6-ylcarbamate serves as a versatile scaffold for medicinal chemistry, enabling efficient access to constrained azabicyclic systems. The protected amine facilitates selective functionalization and compatibility with standard coupling reactions. Its spirocyclic core imparts rigidity, enhancing target binding affinity in drug discovery. Bench-stable and readily purified, it functions as a key building block in the synthesis of bioactive heterocycles and API intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   50.36
  • LogP   1.2631
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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