2-Chloro-4-fluoropyridine

Name: 2-Chloro-4-fluoropyridine
Brand: ChemScene
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CAS No. 34941-91-8
Cat. No. CS-W007987
Purity≥97%
MDL No.MFCD04039345

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 34941-91-8
Cat. No. CS-W007987
Purity ≥97%
MDL No. MFCD04039345
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₃ClFN
Molecular Weight 131.54
Synonym(s) 2-Chlor-4-fluorpyridin; 2-Chloro-4-fluoropyridine
SMILES C1=CC(=CC(=N1)Cl)F

Description

2-Chloro-4-fluoropyridine is a heterocyclic building block featuring complementary electrophilic and nucleophilic sites. This electron-deficient pyridine scaffold enables selective functionalization in cross-coupling and nucleophilic substitution reactions. The ortho-chloro and meta-fluoro substituents provide orthogonal reactivity, facilitating sequential derivatization under mild conditions. Bench-stable and moisture-tolerant, it integrates efficiently into complex molecular architectures for pharmaceutical and agrochemical synthesis.

Application

2-Chloro-4-fluoropyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen reactivity. The chloro and fluoro substituents facilitate sequential functionalization, while the pyridine core provides a stable, electron-deficient platform for nucleophilic substitution and transition metal-mediated transformations. Its bench-stable nature and compatibility with diverse reaction conditions make it ideal for constructing complex heterocyclic scaffolds in API development.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS02,GHS07
Signal Word : Danger	UN#: 1993
Class : 3	Packing Group : Ⅲ
Hazard Statements : H226-H302+H312+H332-H315-H319-H335
Precautionary Statements : P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P370+P378-P403+P235-P501

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Computational Chemistry Data

TPSA 12.89
LogP 1.8741
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2-Chloro-4-fluoropyridine

CAS No. 34941-91-8

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