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CS-W001157 4
Total: USD 88.00

2,6-Dichloropyridine

  • CAS No. 2402-78-0

  • Cat. No. CS-W020060
  • Purity≥98%
  • MDL No.MFCD00006244

*For research and further manufacturing use only, not for direct human use.

2,6-Dichloropyridine|CS-W020060

Structure of 2402-78-0

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General Information

  • CAS No. 2402-78-0
  • Cat. No. CS-W020060
  • Purity ≥98%
  • MDL No. MFCD00006244
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃Cl₂N
  • Molecular Weight 147.99
  • Synonym(s) None
  • SMILES ClC1=CC=CC(Cl)=N1

Description

2,6-Dichloropyridine features a rigid heteroaromatic core with chlorine substituents at electron-deficient positions, enabling selective electrophilic substitution and serving as a key scaffold in pharmaceutical synthesis. This bench-stable, moisture-tolerant reagent integrates readily into cross-coupling and functionalization workflows.

Application

2,6-Dichloropyridine serves as a versatile building block in synthetic organic chemistry, enabling selective functionalization at the 3- and 4-positions via palladium-catalyzed cross-coupling reactions. Its orthogonal reactivity profile supports efficient construction of substituted heterocycles and pharmaceutical scaffolds. The molecule exhibits good bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis workflows in medicinal chemistry and process development.

Synthesis

  • Route1
    • null|null
      109-09-1
    • ~73%
    • In-stock
      2,6-Dichloropyridine|CS-W020060
      2402-78-0

    References

    • Choppin, Sabine; Gros, Philippe; Fort, Yves Organic Letters, 2000 , vol. 2, # 6 p. 803 - 805
  • Route2
    • null|null
      2587-00-0
    • ~94%
    • In-stock
      2,6-Dichloropyridine|CS-W020060
      2402-78-0

    References

    • Nakagawa, Hiroshi; Higuchi, Tsunehiko; Kikuchi, Kazuya; Urano, Yasuteru; Nagano, Tetsuo Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 10 p. 1656 - 1657
  • Route3
    • null|null
      2587-00-0
    • ~77%
    • null|null
      109-09-1
    • In-stock
      2,6-Dichloropyridine|CS-W020060
      2402-78-0

    References

    • Singh, Sunil Kumar; Srinivasa Reddy; Mangle, Mangesh; Ravi Ganesh Tetrahedron, 2007 , vol. 63, # 1 p. 126 - 130

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H315-H319
Precautionary Statements : P264-P270-P280-P302+P352-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.3884
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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