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CS-W001157 4
Total: USD 88.00

2-Chloro-4-methylpyridine

  • CAS No. 3678-62-4

  • Cat. No. CS-W011139
  • Purity≥98%
  • MDL No.MFCD00023418

*For research and further manufacturing use only, not for direct human use.

2-Chloro-4-methylpyridine|CS-W011139

Structure of 3678-62-4

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General Information

  • CAS No. 3678-62-4
  • Cat. No. CS-W011139
  • Purity ≥98%
  • MDL No. MFCD00023418
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆ClN
  • Molecular Weight 127.57
  • Synonym(s) 2-Chloro-4-picoline
  • SMILES C1=C(C)C=CN=C1Cl

Description

2-Chloro-4-methylpyridine (2-Chloro-4-picoline) reacts with 3,5-bis(trifluoromethyl)phenylboronic acid to form 2-(3,5-bis(trifluoromethyl)phenyl)-4-methylpyridine by palladium-catalyzed cross-coupling reaction.

Synthesis

  • Route1

    References

    • Kureha Kagaku Kogyo K.K. Patent: US6610853 B1, 2003 ;
  • Route2

    References

    • SmithKline Beecham Corporation Patent: US2002/91264 A1, 2002 ;
  • Route3

    References

    • ISHIHARA SANGYO KAISHA, LTD. Patent: EP1679003 A1, 2006 ; Location in patent: Page/Page column 20-21 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.04342
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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