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CS-W001157 4
Total: USD 88.00

4-Chloro-3-fluoropyridine

  • CAS No. 2546-56-7

  • Cat. No. CS-W001515
  • Purity≥97%
  • MDL No.MFCD03453233

*For research and further manufacturing use only, not for direct human use.

4-Chloro-3-fluoropyridine|CS-W001515

Structure of 2546-56-7

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General Information

  • CAS No. 2546-56-7
  • Cat. No. CS-W001515
  • Purity ≥97%
  • MDL No. MFCD03453233
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃ClFN
  • Molecular Weight 131.54
  • Synonym(s) Pyridine, 4-chloro-3-fluoro-
  • SMILES ClC1=CC=NC=C1F

Description

4-Chloro-3-fluoropyridine features a dual halogen substitution pattern that enables selective cross-coupling and functionalization in pharmaceutical synthesis. The electron-deficient pyridine core pairs with orthogonal reactivity of chlorine and fluorine, facilitating sequential derivatization under mild conditions. This bench-stable heterocycle integrates readily into complex molecular architectures.

Application

4-Chloro-3-fluoropyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen reactivity. The fluorine and chlorine substituents provide distinct electronic modulation and site-specific functionalization potential. Its bench-stable nature and compatibility with standard reaction conditions facilitate efficient synthesis of pyridine-based pharmaceutical intermediates and heterocyclic scaffolds.

Synthesis

  • Route1

    References

    • AVENTIS PHARMACEUTICALS INC. Patent: WO2005/35496 A1, 2005 ; Location in patent: Page/Page column 32 ;
  • Route2
    • 3-Chloro-4,5-difluoropyridine|CS-0060727
      851178-98-8
    • ~%
    • In-stock
      4-Chloro-3-fluoropyridine|CS-W001515
      2546-56-7

    References

    • Chemistry - A European Journal, , vol. 11, # 6 p. 1903 - 1910
  • Route3
    • 3,4-Dichloro-5-fluoropyridine|CS-0673085
      851179-02-7
    • ~%
    • In-stock
      4-Chloro-3-fluoropyridine|CS-W001515
      2546-56-7

    References

    • Chemistry - A European Journal, , vol. 11, # 6 p. 1903 - 1910

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02
Signal Word : Danger
UN#: 1993
Class : 3
Packing Group : Ⅲ
Hazard Statements : H226-H315-H319-H335
Precautionary Statements : P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P370+P378-P403+P235-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   1.8741
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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