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CS-W001157 4
Total: USD 88.00

4-Chloro-3,5-difluoropyridine

  • CAS No. 851178-97-7

  • Cat. No. CS-W018166
  • Purity≥96%
  • MDL No.MFCD09998885

*For research and further manufacturing use only, not for direct human use.

4-Chloro-3,5-difluoropyridine|CS-W018166

Structure of 851178-97-7

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General Information

  • CAS No. 851178-97-7
  • Cat. No. CS-W018166
  • Purity ≥96%
  • MDL No. MFCD09998885
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₂ClF₂N
  • Molecular Weight 149.53
  • Synonym(s) None
  • SMILES FC1=CN=CC(F)=C1Cl

Description

4-Chloro-3,5-difluoropyridine features a highly electron-deficient pyridine core flanked by strategically positioned fluorine and chlorine substituents, enabling selective cross-coupling reactions under mild conditions. This bench-stable heterocycle integrates efficiently into pharmaceutical intermediates and functional materials, offering enhanced reactivity in Pd-catalyzed transformations.

Application

4-Chloro-3,5-difluoropyridine serves as a versatile building block in medicinal chemistry, enabling efficient late-stage functionalization via palladium-catalyzed cross-coupling reactions. Its electron-deficient pyridine core enhances reactivity in nucleophilic substitution processes, while the orthogonal halogenation pattern allows for sequential derivatization. The compound exhibits excellent bench stability and facilitates clean purification, making it well-suited for scalable synthesis of bioactive heterocycles and API intermediates.

Synthesis

  • Route1
    • null|null
      71902-33-5
    • ~71%
    • In-stock
      4-Chloro-3,5-difluoropyridine|CS-W018166
      851178-97-7

    References

    • Bobbio, Carla; Rausis, Thierry; Schlosser, Manfred Chemistry - A European Journal, 2005 , vol. 11, # 6 p. 1903 - 1910
  • Route2
    • 3,5-Difluoro-2-hydrazinylpyridine|CS-0456221
      851179-06-1
    • ~%
    • In-stock
      4-Chloro-3,5-difluoropyridine|CS-W018166
      851178-97-7

    References

    • Chemistry - A European Journal, , vol. 11, # 6 p. 1903 - 1910
  • Route3

    References

    • Chemistry - A European Journal, , vol. 11, # 6 p. 1903 - 1910

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02
Signal Word : Danger
UN#: 1993
Class : 3
Packing Group : Ⅲ
Hazard Statements : H226
Precautionary Statements : P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P370+P378-P403+P235-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.0132
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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