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CS-W001157 4
Total: USD 88.00

4-Carboxy-2-chlorophenylboronic acid

  • CAS No. 851335-09-6

  • Cat. No. CS-W015598
  • Purity≥95%
  • MDL No.MFCD07363763

*For research and further manufacturing use only, not for direct human use.

4-Carboxy-2-chlorophenylboronic acid|CS-W015598

Structure of 851335-09-6

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General Information

  • CAS No. 851335-09-6
  • Cat. No. CS-W015598
  • Purity ≥95%
  • MDL No. MFCD07363763
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆BClO₄
  • Molecular Weight None
  • Synonym(s) benzoic acid, 4-borono-3-chloro-
  • SMILES OB(C1=CC=C(C(O)=O)C=C1Cl)O

Description

4-Carboxy-2-chlorophenylboronic acid features a boronate group flanked by electron-withdrawing carboxy and chloro substituents, enhancing its reactivity in Suzuki-Miyaura couplings. This bench-stable derivative integrates seamlessly into complex molecular architectures, enabling efficient C–C bond formation under mild conditions.

Application

4-Carboxy-2-chlorophenylboronic acid serves as a versatile building block in Suzuki-Miyaura coupling reactions, enabling efficient C–C bond formation under mild conditions. The ortho-chloro and carboxylic acid functionalities provide orthogonal reactivity for downstream modifications, including amide coupling and palladium-catalyzed cross-couplings. Its bench-stable solid form facilitates handling and purification, making it well-suited for the synthesis of functionalized heterocycles and pharmaceutical intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H318
Precautionary Statements : P264-P270-P280-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   77.76
  • LogP   -0.282
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   2

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