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CS-W001157 4
Total: USD 88.00

4-Chloro-2,5-difluoropyridine

  • CAS No. 851386-40-8

  • Cat. No. CS-0044528
  • Purity≥95%
  • MDL No.MFCD09031178

*For research and further manufacturing use only, not for direct human use.

4-Chloro-2,5-difluoropyridine|CS-0044528

Structure of 851386-40-8

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General Information

  • CAS No. 851386-40-8
  • Cat. No. CS-0044528
  • Purity ≥95%
  • MDL No. MFCD09031178
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₂ClF₂N
  • Molecular Weight 149.53
  • Synonym(s) None
  • SMILES FC1=CN=C(F)C=C1Cl

Description

4-Chloro-2,5-difluoropyridine is a fluorinated pyridine derivative featuring complementary halogen substituents that enable selective cross-coupling reactions. This electron-deficient heterocycle integrates readily into medicinal chemistry scaffolds and serves as a key building block in the synthesis of bioactive molecules.

Application

4-Chloro-2,5-difluoropyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen reactivity. The chlorine and fluorine substituents offer complementary sites for selective functionalization, facilitating the construction of complex heterocyclic scaffolds with enhanced metabolic stability. Its bench-stable nature and compatibility with standard reaction conditions make it ideal for iterative synthesis workflows in API development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.0132
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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