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Boc-azaspiro[3.3]heptane-NH-Me

  • CAS No. 1824024-00-1

  • Cat. No. CS-0056259
  • Purity≥97%
  • MDL No.MFCD18642567

*For research and further manufacturing use only, not for direct human use.

Boc-azaspiro[3.3]heptane-NH-Me|CS-0056259

Structure of 1824024-00-1

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General Information

  • CAS No. 1824024-00-1
  • Cat. No. CS-0056259
  • Purity ≥97%
  • MDL No. MFCD18642567
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₂₂N₂O₂
  • Molecular Weight 226.32
  • Synonym(s) None
  • SMILES O=C(OC(C)(C)C)N1CC2(C1)CC(NC)C2

Description

This tert-butyl 6-(methylamino)-2-azaspiro[3.3]heptane-2-carboxylate features a spirocyclic core with a methylamino substituent, delivering enhanced rigidity and defined stereochemistry. The tert-butyl ester group enables convenient deprotection under mild acidic conditions, facilitating downstream functionalization. This scaffold serves as a valuable chiral building block in medicinal chemistry, particularly for targeted kinase inhibitors and CNS-active compounds.

Application

tert-Butyl 6-(methylamino)-2-azaspiro[3.3]heptane-2-carboxylate serves as a versatile spirocyclic scaffold for medicinal chemistry, enabling efficient access to constrained nitrogen-containing heterocycles. The protected amine and carboxylate functionalities offer orthogonal reactivity, facilitating downstream derivatization via amide coupling or reductive amination. Bench-stable and readily purified by flash chromatography, it functions as a key building block in the synthesis of bioactive molecules with defined stereochemistry.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   41.57
  • LogP   1.6053
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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