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CS-W001157 4
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tert-Butyl 3,8-diazaspiro[4.4]nonane-8-carboxylate

  • CAS No. 236406-49-8

  • Cat. No. CS-B1265
  • Purity≥96%
  • MDL No.MFCD03790957

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 3,8-diazaspiro[4.4]nonane-8-carboxylate|CS-B1265

Structure of 236406-49-8

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General Information

  • CAS No. 236406-49-8
  • Cat. No. CS-B1265
  • Purity ≥96%
  • MDL No. MFCD03790957
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₂₂N₂O₂
  • Molecular Weight 226.32
  • Synonym(s) tert-Butyl 2,7-diazaspiro[4.4]nonane-2-carboxylate; tert-Butyl 3,7-diazaspiro[4.4]nonane-3-carboxylate; tert-Butyl 2,7-diazaspiro[4,4]nonane-2-carboxylate
  • SMILES O=C(OC(C)(C)C)N(CC1)CC21CNCC2

Description

tert-Butyl 3,8-diazaspiro[4.4]nonane-8-carboxylate features a rigid spirocyclic core with strategically positioned nitrogen atoms, enabling efficient incorporation into complex heterocyclic scaffolds. The tert-butyl ester group provides stability and facilitates straightforward deprotection under mild acidic conditions. This compound serves as a key building block in the synthesis of bioactive molecules requiring constrained diamine motifs.

Application

tert-Butyl 3,8-diazaspiro[4.4]nonane-8-carboxylate serves as a versatile spirocyclic scaffold for medicinal chemistry and catalytic synthesis. Its tertiary amine functionality and protected carboxylate enable selective functionalization, while the rigid spiro architecture imparts conformational control. The tert-butyl group provides bench stability and facilitates straightforward deprotection under mild acidic conditions, enabling efficient access to free diamine intermediates for downstream applications in heterocycle construction and API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362+P364

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Computational Chemistry Data

  • TPSA   41.57
  • LogP   1.6069
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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