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CS-W001157 4
Total: USD 88.00

(4-Bromo-2,5-difluorophenyl)boronic acid

  • CAS No. 1106676-82-7

  • Cat. No. CS-0175117
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(4-Bromo-2,5-difluorophenyl)boronic acid|CS-0175117

Structure of 1106676-82-7

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General Information

  • CAS No. 1106676-82-7
  • Cat. No. CS-0175117
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄BBrF₂O₂
  • Molecular Weight 236.81
  • Synonym(s) 4-Bromo-2,5-difluorophenylboronic acid
  • SMILES OB(O)C1=C(F)C=C(Br)C(F)=C1

Description

This boronate reagent features a strategically positioned bromine and two fluorine substituents that enhance its stability and modulate electronic properties. The para-fluorinated aryl group enables efficient cross-coupling under standard conditions, while the ortho-bromo functionality facilitates downstream functionalization. Designed for precision in complex synthesis, this bench-stable reagent integrates seamlessly into iterative coupling sequences.

Application

(4-Bromo-2,5-difluorophenyl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient C–C bond formation with aryl and vinyl halides. Its stability under ambient conditions, compatibility with diverse functional groups, and predictable reactivity make it ideal for constructing complex molecular architectures in medicinal chemistry and materials science.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   40.46
  • LogP   0.4071
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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