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CS-W001157 4
Total: USD 88.00

(4-Bromo-2,6-difluorophenyl)boronic acid

  • CAS No. 352535-81-0

  • Cat. No. CS-W014284
  • Purity≥98%
  • MDL No.MFCD03095369

*For research and further manufacturing use only, not for direct human use.

(4-Bromo-2,6-difluorophenyl)boronic acid|CS-W014284

Structure of 352535-81-0

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General Information

  • CAS No. 352535-81-0
  • Cat. No. CS-W014284
  • Purity ≥98%
  • MDL No. MFCD03095369
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄BBrF₂O₂
  • Molecular Weight 236.81
  • Synonym(s) boronic acid, B-(4-bromo-2,6-difluorophenyl)-
  • SMILES OB(C1=C(F)C=C(Br)C=C1F)O

Description

This boronate reagent features a strategically positioned bromine and two fluorine atoms that enhance its reactivity in cross-coupling processes. The electron-deficient aryl ring enables efficient Suzuki-Miyaura coupling under standard conditions, while the bench-stable boronic acid functionality simplifies handling and storage.

Application

(4-Bromo-2,6-difluorophenyl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient C–C bond formation under mild conditions. Its ortho-fluoro substituents enhance metabolic stability and modulate electronic properties, while the boronic acid group offers excellent bench stability and compatibility with diverse functional groups. This reagent facilitates the construction of complex aryl scaffolds prevalent in pharmaceutical and agrochemical development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   40.46
  • LogP   0.4071
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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