Lot numbers can be found on the outside label of a product:
Ethyl 2-methylthiazole-4-carboxylate
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CAS No. 6436-59-5
- Cat. No. CS-W002453
- Purity≥98%
- MDL No.MFCD00156148
*For research and further manufacturing use only, not for direct human use.
Structure of 6436-59-5
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General Information
- CAS No. 6436-59-5
- Cat. No. CS-W002453
- Purity ≥98%
- MDL No. MFCD00156148
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₇H₉NO₂S
- Molecular Weight 171.22
- Synonym(s) Ethyl 2-methyl-1,3-thiazole-4-carboxylate
- SMILES CCOC(=O)c1csc(n1)C
Description
Ethyl 2-methylthiazole-4-carboxylate features a thiazole core with complementary electron-rich and electrophilic sites, enabling direct functionalization at the C4 position. The ethyl ester group facilitates downstream transformations in synthetic sequences. This bench-stable reagent integrates efficiently into heterocyclic synthesis workflows, particularly for medicinal chemistry applications requiring nitrogen- and sulfur-containing scaffolds.
Application
Ethyl 2-methylthiazole-4-carboxylate serves as a versatile building block in medicinal chemistry and heterocyclic synthesis. The thiazole core provides a rigid, electron-deficient scaffold ideal for constructing bioactive molecules. The ester functionality enables facile manipulation via hydrolysis, reduction, or coupling reactions. Its bench-stable nature and compatibility with standard reaction conditions facilitate integration into multi-step syntheses, particularly for kinase inhibitors and other pharmaceutical intermediates.
Synthesis
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Route1
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70-23-5 -
In-stock
62-55-5 - ~96%
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In-stock
6436-59-5
References
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Zhan, Weiqiang; Jiang, Yi; Brodie, Peggy J.; Kingston, David G. I.; Liotta, Dennis C.; Snyder, James P. Organic Letters, 2008 , vol. 10, # 8 p. 1565 - 1568
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Route2
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6436-57-3
- ~93%
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In-stock
6436-59-5
References
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Williams, David R.; Lowder, Patrick D.; Gu, Yu-Gui; Brooks, Dawn A. Tetrahedron Letters, 1997 , vol. 38, # 3 p. 331 - 334
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Route3
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89530-18-7
- ~67%
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In-stock
6436-59-5
References
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Huang, Yue; Gan, Haifeng; Li, Shang; Xu, Jinyi; Wu, Xiaoming; Yao, Hequan Tetrahedron Letters, 2010 , vol. 51, # 13 p. 1751 - 1753
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 39.19
- LogP 1.62822
- H_Acceptors 4
- H_Donors 0
- Rotatable_Bonds 2
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Key Words
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