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CS-W001157 4
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2-Methylthiazole-4-carboxylic acid

  • CAS No. 35272-15-2

  • Cat. No. CS-0037835
  • Purity≥98%
  • MDL No.MFCD03407332

*For research and further manufacturing use only, not for direct human use.

2-Methylthiazole-4-carboxylic acid|CS-0037835

Structure of 35272-15-2

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General Information

  • CAS No. 35272-15-2
  • Cat. No. CS-0037835
  • Purity ≥98%
  • MDL No. MFCD03407332
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₅NO₂S
  • Molecular Weight 143.16
  • Synonym(s) 2-Methyl-1,3-thiazole-4-carboxylic acid
  • SMILES CC1=NC(=CS1)C(=O)O

Description

2-Methylthiazole-4-carboxylic acid features a fused thiazole ring with a methyl group at the 2-position and a carboxylic acid function at the 4-position, delivering enhanced solubility and reactivity in synthetic transformations. This scaffold integrates readily into bioactive molecules and serves as a key building block for medicinal chemistry applications.

Application

2-Methylthiazole-4-carboxylic acid serves as a versatile building block for heterocyclic synthesis, enabling efficient access to thiazole-based scaffolds prevalent in medicinal chemistry. Its carboxylic acid functionality facilitates direct coupling reactions and derivatization under standard amide formation conditions. The molecule exhibits good bench stability and functional group tolerance, supporting its use in multi-step syntheses and API development workflows.

Synthesis

  • Route1

    References

    • Jaeschke, Georg; Kolczewski, Sabine; Porter, Richard H.P.; Schnider, Patrick; Vieira, Eric Patent: US2007/105891 A1, 2007 ; Location in patent: Page/Page column 10 ; US 20070105891 A1
  • Route2

    References

    • US6472404 B1, ;
  • Route3
    • 2-Methylthiazole-4,5-dicarboxylic acid|CS-0880538
      856353-20-3
    • ~%
    • In-stock
      2-Methylthiazole-4-carboxylic acid|CS-0037835
      35272-15-2

    References

    • Chemische Berichte, , vol. 73, p. 1240,1252

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.14972
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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