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CS-W001157 4
Total: USD 88.00

2-Ethynylthiazole-4-carboxylic acid

  • CAS No. 2246923-22-6

  • Cat. No. CS-0612691
  • Molecule weightNone
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Ethynylthiazole-4-carboxylic acid|CS-0612691

Structure of 2246923-22-6

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General Information

  • CAS No. 2246923-22-6
  • Cat. No. CS-0612691
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃NO₂S
  • Molecular Weight None
  • Synonym(s) 2-ethynyl-1,3-thiazole-4-carboxylic acid
  • SMILES O=C(C1=CSC(C#C)=N1)O

Description

2-Ethynylthiazole-4-carboxylic acid features a reactive alkyne group conjugated to an electron-deficient thiazole ring, enabling efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC). This scaffold integrates readily into bioconjugation workflows and modular synthesis, offering high functional group tolerance and stability under standard conditions.

Application

2-Ethynylthiazole-4-carboxylic acid serves as a versatile building block for the synthesis of thiazole-based heterocycles and bioactive molecules. Its terminal alkyne functionality enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC), while the carboxylic acid group supports direct amidation or esterification, facilitating conjugation in medicinal chemistry and materials science applications. The compound exhibits good bench stability and is readily purified by recrystallization.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P260-P264-P270-P271-P280-P301+P310-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   0.8226
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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