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CS-W001157 4
Total: USD 88.00

(3-Bromo-2-fluorophenyl)boronic acid

  • CAS No. 352535-97-8

  • Cat. No. CS-W014779
  • Purity≥98%
  • MDL No.MFCD05664228

*For research and further manufacturing use only, not for direct human use.

(3-Bromo-2-fluorophenyl)boronic acid|CS-W014779

Structure of 352535-97-8

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General Information

  • CAS No. 352535-97-8
  • Cat. No. CS-W014779
  • Purity ≥98%
  • MDL No. MFCD05664228
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅BBrFO₂
  • Molecular Weight 218.82
  • Synonym(s) boronic acid, B-(3-bromo-2-fluorophenyl)-
  • SMILES FC1=C(Br)C=CC=C1B(O)O

Description

This boronate moiety features a strategically positioned bromine and fluorine substituent, enabling selective cross-coupling reactions under standard conditions. The ortho-fluorine enhances stability and directs regioselective palladium-catalyzed transformations, while the boronic acid group facilitates efficient Suzuki-Miyaura coupling with minimal protodeboronation.

Application

(3-Bromo-2-fluorophenyl)boronic acid serves as a versatile building block in palladium-catalyzed cross-coupling reactions, enabling efficient C–C bond formation under standard Suzuki-Miyaura conditions. The ortho-fluoro and bromo substituents provide complementary reactivity for sequential functionalization, while the boronic acid group offers excellent bench stability and ease of purification. Its defined regiochemistry facilitates reliable access to substituted biaryls and heterocyclic scaffolds relevant to pharmaceutical discovery and materials chemistry.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   40.46
  • LogP   0.268
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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