(R)-(Tetrahydrofuran-3-yl)methanamine

Name: (R)-(Tetrahydrofuran-3-yl)methanamine
Brand: ChemScene
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CAS No. 1048962-82-8
Cat. No. CS-0053315
Purity≥97%
MDL No.None

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(R)-(Tetrahydrofuran-3-yl)methanamine|CS-0053315

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General Information

CAS No. 1048962-82-8
Cat. No. CS-0053315
Purity ≥97%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₁₁NO
Molecular Weight 101.15
Synonym(s) (R)-1-Tetrahydrofuran-3-ylmethanamine
SMILES NC[C@H]1CCOC1

Description

(R)-(Tetrahydrofuran-3-yl)methanamine is a chiral amine featuring a tetrahydrofuran ring with a methylene-amino group at the 3-position. This configuration enables stereoselective synthesis in medicinal chemistry, offering enhanced control in asymmetric transformations. The molecule’s rigid cyclic framework promotes defined spatial orientation, improving binding specificity in target-directed drug development.

Application

(R)-(Tetrahydrofuran-3-yl)methanamine serves as a versatile chiral building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and peptidomimetics. Its tetrahydrofuran ring provides conformational rigidity and metabolic stability, while the primary amine facilitates straightforward functionalization via alkylation, acylation, or coupling reactions. Bench-stable and readily purified by standard chromatographic methods, it functions effectively in multi-step syntheses requiring stereocontrol.

Safety Information

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GHS Pictogram :	GHS No : GHS02,GHS05
Signal Word : Danger	UN#: 1993
Class : 3	Packing Group : Ⅲ
Hazard Statements : H226-H315-H318-H335
Precautionary Statements : P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P370+P378-P403+P235-P501

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Computational Chemistry Data

TPSA 35.25
LogP -0.0184
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Building Blocks Skeleton Aliphatic heterocycle compounds Tetrahydrofuran compounds

Key Words

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(R)-(Tetrahydrofuran-3-yl)methanamine

CAS No. 1048962-82-8

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