2-Chloro-4-methoxy-5-nitropyridine

Name: 2-Chloro-4-methoxy-5-nitropyridine
Brand: ChemScene
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CAS No. 607373-83-1
Cat. No. CS-0042345
Purity≥95%
MDL No.MFCD09907961

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-Chloro-4-methoxy-5-nitropyridine|CS-0042345

Structure of 607373-83-1

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General Information

CAS No. 607373-83-1
Cat. No. CS-0042345
Purity ≥95%
MDL No. MFCD09907961
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₅ClN₂O₃
Molecular Weight 188.57
Synonym(s) None
SMILES O=[N+](C1=CN=C(Cl)C=C1OC)[O-]

Description

2-Chloro-4-methoxy-5-nitropyridine features a nitro group at C5 and a chloro substituent at C2, creating a highly electron-deficient pyridine core. This configuration enables direct coupling in cross-coupling reactions, while the methoxy group enhances solubility and modulates reactivity. The compound serves as a key intermediate in the synthesis of bioactive heterocycles.

Application

2-Chloro-4-methoxy-5-nitropyridine serves as a versatile building block in heterocyclic synthesis, enabling efficient late-stage functionalization via palladium-catalyzed cross-coupling reactions. The ortho-chloro group exhibits high reactivity in Suzuki, Stille, and Buchwald–Hartwig transformations, while the methoxy and nitro substituents provide orthogonal handles for selective derivatization. Bench-stable and compatible with standard purification protocols, it facilitates the construction of complex pyridine-based scaffolds relevant to medicinal chemistry and agrochemical development.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 65.26
LogP 1.6518
H_Acceptors 4
H_Donors 0
Rotatable_Bonds 2

Other Classifications

Building Blocks Functional Group Nitro compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2-Chloro-4-methoxy-5-nitropyridine

CAS No. 607373-83-1

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