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CS-W001157 4
Total: USD 88.00

3-Hydroxypyridine-4-carboxylic acid

  • CAS No. 10128-71-9

  • Cat. No. CS-W001841
  • Purity≥95%
  • MDL No.MFCD00234165

*For research and further manufacturing use only, not for direct human use.

3-Hydroxypyridine-4-carboxylic acid|CS-W001841

Structure of 10128-71-9

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General Information

  • CAS No. 10128-71-9
  • Cat. No. CS-W001841
  • Purity ≥95%
  • MDL No. MFCD00234165
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅NO₃
  • Molecular Weight 139.11
  • Synonym(s) 4-Pyridinecarboxylic acid, 3-hydroxy-
  • SMILES OC(=O)c1ccncc1O

Description

DBCO-S-S-acid is a cleavable reagent for introduction of a carboxylic acid moiety to azide-containing biomolecules using copper-free Click Chemistry. PEG spacer arm provides better solubility to the labeled molecules in aqueous media. The disulfide bond in this linker can be cleaved using reducing agents such as DTT, BME and TCEP.

Synthesis

  • Route1

    References

    • Miknis, Greg; Lyssikatos, Joseph P.; Laird, Ellen; Tarlton, Eugene; Buckmelter, Alexandre J.; Ren, Li; Rast, Bryson; Schlacter, Stephen T.; Wenglowsky, Steven Mark Patent: US2007/49603 A1, 2007 ; Location in patent: Page/Page column 78; 30 ; US 20070049603 A1
  • Route2
    • 5-Ethoxyoxazole|CS-1660886
      15031-12-6
    • null|null
      79-10-7
    • ~30%
    • In-stock
      3-Hydroxypyridine-4-carboxylic acid|CS-W001841
      10128-71-9

    References

    • Johnsen, Bjoern A.; Undheim, Kjell Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1983 , vol. 37, # 2 p. 127 - 132
  • Route3
    • Isonicotinic acid Nicotinic Acid  Impurity|CS-0229405
      55-22-1
    • ~%
    • In-stock
      3-Hydroxypyridine-4-carboxylic acid|CS-W001841
      10128-71-9

    References

    • Heterocyclic Communications, , vol. 9, # 5 p. 489 - 492

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   70.42
  • LogP   0.4854
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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