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CS-W001157 4
Total: USD 88.00

4-(Hydroxymethyl)pyridin-3-ol

  • CAS No. 33349-67-6

  • Cat. No. CS-0157312
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-(Hydroxymethyl)pyridin-3-ol|CS-0157312

Structure of 33349-67-6

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General Information

  • CAS No. 33349-67-6
  • Cat. No. CS-0157312
  • Purity ≥96%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇NO₂
  • Molecular Weight 125.13
  • Synonym(s) 4-Pyridinemethanol,3-hydroxy-(6CI,8CI,9CI)
  • SMILES C1=C(CO)C(=CN=C1)O

Description

4-(Hydroxymethyl)pyridin-3-ol features a pyridine ring bearing both hydroxyl and hydroxymethyl groups in a strategic ortho arrangement, enabling dual functionalization. This scaffold integrates readily into synthetic pathways requiring polar, electron-rich heterocycles with enhanced solubility and hydrogen-bonding capacity under standard conditions.

Application

4-(Hydroxymethyl)pyridin-3-ol serves as a versatile building block in medicinal chemistry, enabling efficient access to functionalized heterocyclic scaffolds. Its ortho-hydroxyl and hydroxymethyl groups provide complementary reactivity for derivatization, including etherification, oxidation, and metal-catalyzed coupling reactions. The compound exhibits good bench stability and facilitates purification via standard chromatographic methods, supporting its use in multi-step syntheses of bioactive molecules and API intermediates.

Synthesis

  • Route1

    References

    • Heinert; Martell Tetrahedron, 1958 , vol. 3, p. 49,56
  • Route2

    References

    • Heinert; Martell Tetrahedron, 1958 , vol. 3, p. 49,56

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   53.35
  • LogP   0.2795
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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