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CS-W001157 4
Total: USD 88.00

4-(4-ethylpiperazino)aniline

  • CAS No. 115619-01-7

  • Cat. No. CS-W002669
  • Purity≥98%
  • MDL No.MFCD00702246

*For research and further manufacturing use only, not for direct human use.

4-(4-ethylpiperazino)aniline|CS-W002669

Structure of 115619-01-7

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General Information

  • CAS No. 115619-01-7
  • Cat. No. CS-W002669
  • Purity ≥98%
  • MDL No. MFCD00702246
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₉N₃
  • Molecular Weight 205.30
  • Synonym(s) ART-CHEM-BB B021943
  • SMILES CCN1CCN(CC1)c1ccc(cc1)N

Description

4-(4-Ethylpiperazin-1-yl)phenylamine features a conjugated arylamine core linked to a sterically accessible ethylpiperazine moiety, enabling effective integration into bioactive scaffolds. This electron-rich amine pair facilitates hydrogen bonding and dipole interactions in pharmaceutical design, offering enhanced solubility and metabolic stability under standard conditions.

Application

4-(4-Ethylpiperazin-1-yl)phenylamine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocyclic scaffolds. Its electron-rich piperazine moiety facilitates amide coupling and reductive amination reactions, while the aniline handle supports direct functionalization. The compound exhibits good bench stability and solubility, simplifying purification and integration into multi-step syntheses.

Synthesis

  • Route1
    • 1-Ethyl-4-(4-nitrophenyl)piperazine|CS-W002646
      115619-00-6
    • ~95%
    • In-stock
      4-(4-ethylpiperazino)aniline|CS-W002669
      115619-01-7

    References

    • Journal of Medicinal Chemistry, , vol. 54, # 20 p. 7066 - 7083
  • Route2
    • null|null
      5308-25-8
    • ~%
    • In-stock
      4-(4-ethylpiperazino)aniline|CS-W002669
      115619-01-7

    References

    • European Journal of Medicinal Chemistry, , vol. 46, # 7 p. 2917 - 2929
  • Route3
    • null|null
      636-98-6
    • ~%
    • In-stock
      4-(4-ethylpiperazino)aniline|CS-W002669
      115619-01-7

    References

    • European Journal of Medicinal Chemistry, , vol. 46, # 7 p. 2917 - 2929

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3259
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   32.5
  • LogP   1.4107
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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