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CS-W001157 4
Total: USD 88.00

1-(2-Fluoro-4-hydroxyphenyl)ethanone

  • CAS No. 98619-07-9

  • Cat. No. CS-M1008
  • Purity≥95%
  • MDL No.MFCD00142713

*For research and further manufacturing use only, not for direct human use.

1-(2-Fluoro-4-hydroxyphenyl)ethanone|CS-M1008

Structure of 98619-07-9

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General Information

  • CAS No. 98619-07-9
  • Cat. No. CS-M1008
  • Purity ≥95%
  • MDL No. MFCD00142713
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇FO₂
  • Molecular Weight 154.14
  • Synonym(s) 2'-Fluoro-4'-hydroxyacetophenone
  • SMILES O=C(C)C1=C(F)C=C(O)C=C1

Description

1-(2-Fluoro-4-hydroxyphenyl)ethanone features a fluorinated aromatic ring paired with a hydroxyl group and ketone functionality, enabling direct integration into bioactive molecule scaffolds. This compound serves as a key intermediate for pharmaceuticals and agrochemicals, offering enhanced metabolic stability and targeted electronic properties through its strategic substitution pattern.

Application

1-(2-Fluoro-4-hydroxyphenyl)ethanone serves as a versatile building block in medicinal chemistry, enabling the synthesis of fluorinated aryl ketones and heterocyclic scaffolds. Its hydroxyl and fluoro substituents provide orthogonal functionalization sites, while the acetyl group facilitates electrophilic transformations and conjugation reactions. The compound exhibits good bench stability and is compatible with standard purification techniques, making it well-suited for iterative synthetic workflows in API development.

Synthesis

  • Route1

    References

    • Organic Preparations and Procedures International, , vol. 41, # 5 p. 419 - 421
  • Route2
    • In-stock
      3-Fluorophenol|CS-W020028
      372-20-3
    • null|null
      75-36-5
    • ~%
    • In-stock
      1-(2-Fluoro-4-hydroxyphenyl)ethanone|CS-M1008
      98619-07-9

    References

    • Journal of Medicinal Chemistry, , vol. 29, # 11 p. 2329 - 2334

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   1.7339
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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