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CS-W001157 4
Total: USD 88.00

2'-Fluoro-4'-methoxyacetophenone

  • CAS No. 74457-86-6

  • Cat. No. CS-W008763
  • Purity≥98%
  • MDL No.MFCD00042290

*For research and further manufacturing use only, not for direct human use.

2'-Fluoro-4'-methoxyacetophenone|CS-W008763

Structure of 74457-86-6

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General Information

  • CAS No. 74457-86-6
  • Cat. No. CS-W008763
  • Purity ≥98%
  • MDL No. MFCD00042290
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₉FO₂
  • Molecular Weight 168.17
  • Synonym(s) N-hydroxy-2-(trifluoromethyl)benzimidoyl chloride
  • SMILES COC1=CC=C(C(C)=O)C(F)=C1

Description

2'-Fluoro-4'-methoxyacetophenone features a fluorine atom at the ortho position and a methoxy group at the para position relative to the acetyl moiety, delivering enhanced electronic modulation and improved solubility in polar organic solvents. This combination enables efficient coupling in cross-coupling reactions and facilitates access to complex aromatic architectures under standard conditions.

Synthesis

  • Route1
    • In-stock
      1-Fluoro-3-methoxybenzene|CS-W013500
      456-49-5
    • null|null
      108-24-7
    • ~63%
    • In-stock
      2'-Fluoro-4'-methoxyacetophenone|CS-W008763
      74457-86-6

    References

    • Hartmann; Heindl; Schwarz; Schonenberger Journal of Medicinal Chemistry, 1984 , vol. 27, # 7 p. 819 - 824
  • Route2

    References

    • Tetrahedron Letters, , vol. 43, # 36 p. 6331 - 6333
  • Route3

    References

    • US5847008 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.3
  • LogP   2.0369
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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