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CS-W001157 4
Total: USD 88.00

3-Fluorophenol

  • CAS No. 372-20-3

  • Cat. No. CS-W020028
  • Purity≥98%
  • MDL No.MFCD00002254

*For research and further manufacturing use only, not for direct human use.

3-Fluorophenol|CS-W020028

Structure of 372-20-3

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General Information

  • CAS No. 372-20-3
  • Cat. No. CS-W020028
  • Purity ≥98%
  • MDL No. MFCD00002254
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅FO
  • Molecular Weight 112.10
  • Synonym(s) M-FLUOROPHENOL
  • SMILES OC1=CC=CC(F)=C1

Description

3-Fluorophenol serves as a key building block in pharmaceutical and agrochemical synthesis, offering a reactive phenolic hydroxyl group flanked by a fluorine atom at the meta position. This combination imparts enhanced metabolic stability and modulates electronic properties, enabling efficient incorporation into bioactive scaffolds under standard conditions.

Application

3-Fluorophenol serves as a versatile building block in medicinal chemistry and materials science, enabling efficient functionalization via electrophilic substitution and transition-metal-catalyzed coupling reactions. Its fluorinated aromatic core provides enhanced metabolic stability and modulated electronic properties, while the phenolic hydroxyl group facilitates straightforward derivatization through etherification, esterification, or direct metalation. Bench-stable and compatible with common protecting group strategies, it functions reliably in multi-step syntheses of pharmaceutical intermediates and specialty polymers.

Synthesis

  • Route1

    References

    • Mulakayala, Naveen; Ismail; Kumar, Kottur Mohan; Rapolu, Rajesh Kumar; Kandagatla, Bhaskar; Rao, Pallavi; Oruganti, Srinivas; Pal, Manojit Tetrahedron Letters, 2012 , vol. 53, # 45 p. 6004 - 6007,4
  • Route2
    • null|null
      591-27-5
    • ~96%
    • In-stock
      3-Fluorophenol|CS-W020028
      372-20-3

    References

    • Yoneda; Fukuhara Tetrahedron, 1996 , vol. 52, # 1 p. 23 - 36
  • Route3
    • null|null
      205187-05-9
    • ~92%
    • In-stock
      3-Fluorophenol|CS-W020028
      372-20-3

    References

    • Morin, Justin; Zhao, Yigang; Snieckus, Victor Organic Letters, 2013 , vol. 15, # 16 p. 4102 - 4105

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS06
Signal Word : Danger
UN#: 2922
Class : 8 (6.1)
Packing Group : Ⅲ
Hazard Statements : H227-H301+H311+H331-H314-H412
Precautionary Statements : P210-P260-P261-P264-P270-P271-P273-P280-P301+P330+P331-P302+P352-P303+P361+P353-P304+P340-P305+P351+P338-P330-P361+P364-P363-P370+P378-P403-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   1.5313
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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