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CS-W001157 4
Total: USD 88.00

2-Bromo-4,6-difluorophenol

  • CAS No. 98130-56-4

  • Cat. No. CS-W015188
  • Purity≥98%
  • MDL No.MFCD00070752

*For research and further manufacturing use only, not for direct human use.

2-Bromo-4,6-difluorophenol|CS-W015188

Structure of 98130-56-4

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General Information

  • CAS No. 98130-56-4
  • Cat. No. CS-W015188
  • Purity ≥98%
  • MDL No. MFCD00070752
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃BrF₂O
  • Molecular Weight 208.99
  • Synonym(s) None
  • SMILES OC1=C(F)C=C(F)C=C1Br

Description

2-Bromo-4,6-difluorophenol delivers a trifunctional aryl platform featuring bromine and two fluorine substituents at meta and para positions relative to the hydroxyl group. This electron-deficient phenol enables direct coupling in cross-coupling reactions and serves as a key intermediate in agrochemical and pharmaceutical synthesis. The molecule exhibits enhanced stability under standard bench conditions and tolerates a range of reaction environments.

Application

2-Bromo-4,6-difluorophenol serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient access to substituted aromatic systems. Its ortho-bromine and para-fluorine substituents facilitate palladium-catalyzed cross-coupling reactions, while the phenolic hydroxyl group supports derivatization and protection strategies. The compound exhibits good bench stability and is compatible with standard synthetic workflows, making it a practical choice for constructing complex heterocyclic scaffolds and functionalized aryl intermediates.

Synthesis

  • Route1

    References

    • Journal of the American Chemical Society, , vol. 81, p. 94,95, 97
  • Route2

    References

    • Journal of the American Chemical Society, , vol. 81, p. 94,95, 97
  • Route3
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      1043421-43-7
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    • In-stock
      2-Bromo-4,6-difluorophenol|CS-W015188
      98130-56-4

    References

    • Organic Process Research and Development, , vol. 16, # 4 p. 704 - 709

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302+H312+H332-H315-H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P501

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   2.4329
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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