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CS-W001157 4
Total: USD 88.00

2,4-Difluoroaniline

  • CAS No. 367-25-9

  • Cat. No. CS-W020027
  • Purity≥98%
  • MDL No.MFCD00007648

*For research and further manufacturing use only, not for direct human use.

2,4-Difluoroaniline|CS-W020027

Structure of 367-25-9

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General Information

  • CAS No. 367-25-9
  • Cat. No. CS-W020027
  • Purity ≥98%
  • MDL No. MFCD00007648
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅F₂N
  • Molecular Weight None
  • Synonym(s) 2,4-Difluorobenzenamine; 2,4-Difluorophenylamine; NSC 10297; 2,4-Difluoro Aniline
  • SMILES NC1=CC=C(F)C=C1F

Description

2,4-Difluoroaniline features two fluorine atoms at the 2- and 4-positions of the aniline ring, imparting enhanced electron-withdrawing character and improved metabolic stability. This ortho- and para-fluorinated scaffold integrates readily into pharmaceutical intermediates, enabling efficient coupling reactions under mild conditions. The molecule exhibits favorable solubility in common organic solvents and maintains stability during standard bench handling.

Application

2,4-Difluoroaniline serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling direct incorporation of fluorinated aromatic scaffolds. Its ortho- and para-fluorine substituents facilitate subsequent cross-coupling reactions and nucleophilic aromatic substitution, while the primary amine functions as a key handle for derivatization. The compound exhibits good bench stability and is compatible with standard purification methods, making it well-suited for use in multi-step synthetic sequences requiring functional group tolerance and predictable reactivity.

Synthesis

  • Route1

    References

    • Rhone-Poulenc Chimie Patent: US5856577 A1, 1999 ;
  • Route2

    References

    • Mason; Milner Synthetic Communications, 1994 , vol. 24, # 4 p. 529 - 532
  • Route3
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      88-73-3
    • ~%
    • In-stock
      2,4-Difluoroaniline|CS-W020027
      367-25-9

    References

    • US4145364 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2941
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H302-H311-H331
Precautionary Statements : P261-P271-P280-P302+P352-P304+P340-P311-P312-P361-P363-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   1.547
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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