3-Chloro-2,4-difluoroaniline

Name: 3-Chloro-2,4-difluoroaniline
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CAS No. 2613-34-5
Cat. No. CS-B0682
Purity≥98%
MDL No.MFCD00042200

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 2613-34-5
Cat. No. CS-B0682
Purity ≥98%
MDL No. MFCD00042200
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₄ClF₂N
Molecular Weight 163.55
Synonym(s) 2,4-Difluoro-3-chloroaniline; 3-Chloro-2,4-difluoro-phenylamine
SMILES NC1=CC=C(F)C(Cl)=C1F

Description

3-Chloro-2,4-difluoroaniline features a strategically positioned chloro and two fluoro substituents that enhance electron withdrawal and metabolic stability. This bench-stable aryl amine integrates readily into pharmaceutical intermediates and agrochemical scaffolds, offering predictable reactivity in coupling and cyclization processes under standard conditions.

Application

3-Chloro-2,4-difluoroaniline serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient construction of heterocyclic scaffolds via electrophilic substitution and coupling reactions. Its ortho-fluoro substituents facilitate directed metallation and Suzuki-Miyaura coupling, while the chloro group provides a handle for nucleophilic displacement. The compound exhibits good bench stability and is compatible with standard purification protocols, making it well-suited for iterative synthetic campaigns requiring functional group tolerance and predictable reactivity.

Synthesis

Route1
- In-stock
  
  3847-58-3
- ~91%
- In-stock
  
  2613-34-5
References
- Tabart, Michel; Picaut, Guy; Lavergne, Marc; Wentzler, Sylvie; Malleron, Jean-Luc; Dutka-Malen, Sylvie; Berthaud, Nadine Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 7 p. 1329 - 1331

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 26.02
LogP 2.2004
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

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3-Chloro-2,4-difluoroaniline

CAS No. 2613-34-5

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