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CS-W001157 4
Total: USD 88.00

3-Chloro-2,6-difluoroaniline

  • CAS No. 287172-82-1

  • Cat. No. CS-0107069
  • Purity≥98%
  • MDL No.MFCD06660173

*For research and further manufacturing use only, not for direct human use.

3-Chloro-2,6-difluoroaniline|CS-0107069

Structure of 287172-82-1

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General Information

  • CAS No. 287172-82-1
  • Cat. No. CS-0107069
  • Purity ≥98%
  • MDL No. MFCD06660173
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄ClF₂N
  • Molecular Weight 163.55
  • Synonym(s) 3-Chloro-2,6-difluoro-phenylamine
  • SMILES NC1=C(F)C=CC(Cl)=C1F

Description

3-Chloro-2,6-difluoroaniline features a trifluorinated aromatic core with strategically positioned halogens enabling selective coupling reactions. This electron-deficient aniline derivative serves as a key intermediate in the synthesis of pharmaceuticals and agrochemicals, offering enhanced reactivity under standard conditions.

Application

3-Chloro-2,6-difluoroaniline serves as a valuable building block in medicinal chemistry and agrochemical synthesis, offering orthogonal reactivity through its complementary halogen substituents. The molecule enables selective coupling reactions via palladium-catalyzed cross-coupling protocols, with the chloro group acting as a reliable electrophilic handle. Its bench-stable nature and tolerance to diverse functional groups facilitate efficient downstream transformations, making it a practical choice for constructing complex heterocyclic scaffolds and API intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H332-H335
Precautionary Statements : P233-P260-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P340-P362-P403-P405-P501

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   2.2004
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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