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CS-W001157 4
Total: USD 88.00

Aniline, 5-chloro-2,4-difluoro-

  • CAS No. 348-65-2

  • Cat. No. CS-0028291
  • Purity≥97%
  • MDL No.MFCD06808806

*For research and further manufacturing use only, not for direct human use.

Aniline, 5-chloro-2,4-difluoro-|CS-0028291

Structure of 348-65-2

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General Information

  • CAS No. 348-65-2
  • Cat. No. CS-0028291
  • Purity ≥97%
  • MDL No. MFCD06808806
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄ClF₂N
  • Molecular Weight 163.55
  • Synonym(s) 2,4 - difluoro -5- chloroaniline
  • SMILES ClC1=C(C=C(F)C(N)=C1)F

Description

5-Chloro-2,4-difluoroaniline delivers a trifunctional aromatic scaffold featuring chlorine and two fluorine substituents at strategic positions. This electron-deficient aniline integrates readily into pharmaceutical intermediates and agrochemical frameworks, offering enhanced metabolic stability and tunable reactivity under standard coupling conditions.

Application

5-Chloro-2,4-difluoroaniline serves as a valuable building block in medicinal chemistry and agrochemical synthesis, enabling the construction of diverse heterocyclic scaffolds. Its orthogonal reactivity profile—driven by strategically positioned halogens—facilitates palladium-catalyzed cross-coupling reactions and nucleophilic aromatic substitution. The compound exhibits excellent bench stability and is compatible with standard purification protocols, making it well-suited for scalable synthesis and process development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   2.2004
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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