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CS-W001157 4
Total: USD 88.00

2,4-Difluorophenol

  • CAS No. 367-27-1

  • Cat. No. CS-W013441
  • Purity≥98%
  • MDL No.MFCD00009715

*For research and further manufacturing use only, not for direct human use.

2,4-Difluorophenol|CS-W013441

Structure of 367-27-1

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General Information

  • CAS No. 367-27-1
  • Cat. No. CS-W013441
  • Purity ≥98%
  • MDL No. MFCD00009715
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄F₂O
  • Molecular Weight 130.09
  • Synonym(s) None
  • SMILES OC1=CC=C(F)C=C1F

Description

2,4-Difluorophenol has been used:as starting reagent during the synthesis of 4,6-difluoro-5,7-dihydroxytryptaminein the synthesis of 3-carboxy-6,8-difluoro-7-hydroxycoumarin (Pacific Blue), fluorinated fluorescent dye

Application

2,4-Difluorophenol serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient introduction of fluorinated aromatic motifs. Its ortho- and para-fluoro substituents facilitate electrophilic substitution and palladium-catalyzed coupling reactions, while the phenolic hydroxyl group supports direct functionalization or protection strategies. The compound exhibits good bench stability and compatibility with standard purification techniques, making it well-suited for iterative synthetic workflows.

Synthesis

  • Route1
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      132303-32-3
    • ~%
    • In-stock
      2,4-Difluorophenol|CS-W013441
      367-27-1

    References

    • WO2005/92858 A2, ; Page/Page column 78-79 ; WO 2005/092858 A2
  • Route2

    References

    • Journal of Organic Chemistry, , vol. 66, # 2 p. 633 - 634
  • Route3

    References

    • Chemische Berichte, , vol. 70, p. 2396,2400

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1760
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302+H312+H332-H315-H318-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   1.6704
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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