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CS-W001157 4
Total: USD 88.00

1,4-Dioxaspiro[4.5]decan-8-ol

  • CAS No. 22428-87-1

  • Cat. No. CS-W007474
  • Purity≥98%
  • MDL No.MFCD00067003

*For research and further manufacturing use only, not for direct human use.

1,4-Dioxaspiro[4.5]decan-8-ol|CS-W007474

Structure of 22428-87-1

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General Information

  • CAS No. 22428-87-1
  • Cat. No. CS-W007474
  • Purity ≥98%
  • MDL No. MFCD00067003
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₄O₃
  • Molecular Weight 158.20
  • Synonym(s) 1,4-Dioxaspiro(4.5)decan-8-ol
  • SMILES OC(CC1)CCC21OCCO2

Description

1,4-Dioxaspiro[4.5]decan-8-ol features a rigid spirocyclic core with two oxygen atoms at the bridgehead positions, delivering exceptional structural stability. The hydroxyl group at C8 provides a polar handle for derivatization, while the saturated framework ensures compatibility with diverse synthetic transformations under standard conditions.

Application

1,4-Dioxaspiro[4.5]decan-8-ol serves as a versatile scaffold for the synthesis of bioactive molecules, leveraging its rigid spirocyclic framework and strategically positioned hydroxyl and ether functionalities. The molecule exhibits excellent bench stability and facilitates efficient functional group interconversions, enabling straightforward derivatization in standard organic transformations. Its defined stereochemistry and compatibility with common protecting group strategies make it a practical building block for medicinal chemistry campaigns requiring controlled molecular architecture.

Synthesis

  • Route1

    References

    • CRYPTOPHARMA PTY LTD Patent: WO2008/124878 A1, 2008 ; Location in patent: Page/Page column 82-83 ;
  • Route2

    References

    • US4366172 S1, ;
  • Route3
    • 1,4-Dioxaspiro[4.5]decan-6-ol|CS-0744438
      78881-14-8
    • null|null
      16940-66-2
    • In-stock
      1,4-Dioxaspiro[4.5]decan-8-one|CS-W008827
      4746-97-8
    • ~%
    • In-stock
      1,4-Dioxaspiro[4.5]decan-8-ol|CS-W007474
      22428-87-1

    References

    • US5808146 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   38.69
  • LogP   0.6644
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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