Lot numbers can be found on the outside label of a product:
2-Boc-2-Azaspiro[3.3]heptane-OH
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CAS No. 1147557-97-8
- Cat. No. CS-D0139
- Purity≥97%
- MDL No.MFCD15071431
*For research and further manufacturing use only, not for direct human use.
![2-Boc-2-Azaspiro[3.3]heptane-OH|CS-D0139](https://file.chemscene.com/productPIC/CS-D0139.gif)
Structure of 1147557-97-8
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General Information
- CAS No. 1147557-97-8
- Cat. No. CS-D0139
- Purity ≥97%
- MDL No. MFCD15071431
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₁H₁₉NO₃
- Molecular Weight 213.28
- Synonym(s) None
- SMILES O=C(OC(C)(C)C)N1CC2(C1)CC(O)C2
Description
tert-Butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate is a sterically encumbered spirocyclic scaffold featuring a hydroxyl group at the 6-position and a bench-stable tert-butyl ester. This configuration enables direct functionalization at the hydroxyl site while maintaining structural rigidity for use in medicinal chemistry and asymmetric synthesis.
Application
tert-Butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate serves as a versatile spirocyclic building block for the synthesis of nitrogen-containing heterocycles, particularly in medicinal chemistry and natural product synthesis. The pendant hydroxyl group enables selective derivatization via esterification or ether formation, while the tert-butyl carbamate offers orthogonal protection for amine functionalization. Its rigid spirocyclic framework provides conformational constraint, facilitating stereocontrolled transformations. The compound exhibits excellent bench stability and is compatible with standard purification methods.
Synthesis
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Route1
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In-stock
![tert-Butyl 6-Oxo-2-azaspiro[3.3]heptane-2-carboxylate|CS-D0133](https://file.chemscene.com/productPIC/CS-D0133.gif)
1181816-12-5 - ~98%
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In-stock
1147557-97-8
References
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BETA PHARMA CANADA INC.; WANG, Zhaoyin; LI, Lianhai; WANG, Zhigang Patent: WO2013/13308 A1, 2013 ; Location in patent: Paragraph 00178-00180 ; WO 2013/013308 A1
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Route2
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![Tert-butyl 6-(benzyloxy)-2-azaspiro[3.3]Heptane-2-carboxylate|CS-0540188](https://file.chemscene.com/productPIC/CS-0540188.gif)
1181816-16-9 - ~%
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In-stock
1147557-97-8
References
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Organic Letters, , vol. 11, # 16 p. 3523 - 3525
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Route3
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In-stock
934664-41-2 - ~%
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In-stock
1147557-97-8
References
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US2012/129830 A1, ;
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 49.77
- LogP 1.3782
- H_Acceptors 3
- H_Donors 1
- Rotatable_Bonds 0
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Key Words
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