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CS-W001157 4
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4-Chloro-6-fluoro-2-(trifluoromethyl)quinazoline

  • CAS No. 959238-11-0

  • Cat. No. CS-0040085
  • Purity≥98%
  • MDL No.MFCD09954902

*For research and further manufacturing use only, not for direct human use.

4-Chloro-6-fluoro-2-(trifluoromethyl)quinazoline|CS-0040085

Structure of 959238-11-0

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General Information

  • CAS No. 959238-11-0
  • Cat. No. CS-0040085
  • Purity ≥98%
  • MDL No. MFCD09954902
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₃ClF₄N₂
  • Molecular Weight 250.58
  • Synonym(s) None
  • SMILES FC(C1=NC(Cl)=C2C=C(F)C=CC2=N1)(F)F

Description

4-Chloro-6-fluoro-2-(trifluoromethyl)quinazoline features a highly electron-deficient core stabilized by orthogonal halogen substituents, enabling direct functionalization in late-stage diversification. This bench-stable scaffold integrates readily into kinase inhibitor frameworks and serves as a key building block for bioactive heterocycles under standard coupling conditions.

Application

4-Chloro-6-fluoro-2-(trifluoromethyl)quinazoline serves as a versatile building block in medicinal chemistry, enabling the construction of kinase inhibitor scaffolds. Its electron-deficient heterocyclic core facilitates nucleophilic substitution and transition-metal-catalyzed coupling reactions. The trifluoromethyl group enhances metabolic stability and lipophilicity, while the halogen substituents provide orthogonal handles for late-stage functionalization. Bench-stable and compatible with standard purification methods, it functions effectively in multistep synthesis workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   3.4411
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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