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CS-W001157 4
Total: USD 88.00

2-Methoxythiazole-5-carbaldehyde

  • CAS No. 95453-59-1

  • Cat. No. CS-W021715
  • Purity≥97%
  • MDL No.MFCD09693732

*For research and further manufacturing use only, not for direct human use.

2-Methoxythiazole-5-carbaldehyde|CS-W021715

Structure of 95453-59-1

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General Information

  • CAS No. 95453-59-1
  • Cat. No. CS-W021715
  • Purity ≥97%
  • MDL No. MFCD09693732
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₅NO₂S
  • Molecular Weight 143.16
  • Synonym(s) 5-Thiazolecarboxaldehyde, 2-methoxy- (9CI)
  • SMILES COC1=NC=C(S1)C=O

Description

2-Methoxythiazole-5-carbaldehyde features a reactive aldehyde group appended to a thiazole scaffold bearing a methoxy substituent. This combination delivers enhanced solubility and stability under standard conditions, enabling direct integration into heterocyclic synthesis workflows. The electron-rich thiazole ring facilitates efficient coupling reactions, while the para-positioned aldehyde serves as a key handle for derivatization in medicinal chemistry and materials development.

Application

2-Methoxythiazole-5-carbaldehyde serves as a versatile heterocyclic building block for medicinal chemistry and process development. Its aldehyde functionality enables direct incorporation into Ugi, Mannich, or reductive amination reactions, while the methoxy group enhances solubility and modulates electronic properties. The thiazole core provides structural rigidity and metabolic stability, making it valuable in the synthesis of kinase inhibitors and other bioactive scaffolds. Bench-stable and compatible with standard protecting group strategies, it facilitates efficient route design and purification.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   39.19
  • LogP   0.9642
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   2

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